Python, DBScan, Hierarchical DBScan, K-Means, Leiden, WGCNA
The mechanism by which neural stem cells develop into neurons, neurogenesis occurs at 10-13 embryonic days. Research performed by Faure et al. (2020) revealed several bifurcation events, leading to the differentiation of proprioceptor, mechanoreceptor, and nociceptor gene clusters. Here, we use data from Faure et al. (2020) and employ various clustering methods to compare results. Our findings include Fxyd7 for proprioception, Itga11 for mechanoreception, Cxcl16, and Trpv1 for nociception. In spite of limited preprocessing and computational power, our results suggest that an ensemble model across multiple clustering methods may be suitable for novel discoveries.